Passive stiffness of the heart is determined largely by extracellular matrix and titin. which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD). while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. https://www.thegreensjunglebeautyshops.shop/product-category/gum-gel/