Abstract Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism remains poorly defined. Using male mouse models of obesity and MASLD. and biopsies from carefully-characterized patients regarding obesity. type 2 diabetes (T2D) and MASLD status. https://thebrickes.shop/product-category/crafts/
Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH
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